Temperament: A Marker for Asthma?

Katie Chun

Have you noticed that certain people tend to get sick, while others do not? Think back to when you were a kid and schools gave out “perfect attendance” awards. Kids who were sick a lot could only dream of this award, while others received this award every single year. Questions about variation in health extend beyond just asking “who gets sick” to also ask “who gets sicker?”. Two people can be exposed to the same bug and one ramps up a significant immune response, knocking him out of work for a week with illness while the other just goes about her normal business as if nothing happened. There are countless examples of how our immune systems react in different ways.

There are lots of potential reasons that people’s immune function differs, but one possibility is that temperament or personality is associated with health. For example, personality traits related to negative affect (i.e. anxiety, hostility) have been consistently related to increased risk for illness. Another example is behavioral inhibition, which is a temperament style commonly studied in children that is similar to shyness. Behaviorally inhibited children tend to avoid social situations and react negatively to new situations. Kids who are behaviorally inhibited as infants and toddlers have a greater risk for developing anxiety later in life than those who are not behaviorally inhibited. In addition to anxiety, behavioral inhibition has also been associated with the development of asthma, a disease characterized by inappropriate responses in the immune system. Unfortunately, the exact way that asthma and behavioral inhibition are related is not yet known.

In a series of studies that I conducted as part of my doctoral work, we used a monkey model to try and understand the link Copyright Kathy West CNPRC 2015between behavioral inhibition and asthma. A common measure of asthma is how sensitive the lungs are to things that enter them (e.g., air pollutants, or aerosols). In asthmatics, the lungs are really reactive, causing constriction and decreasing airflow to produce an asthma attack. We first demonstrated that monkeys that were less likely to socialize with peers and who had more intense reactions to novel situations tended to have more reactive airways (an indicator of asthma) than control monkeys. That is—behavioral patterns associated with social behavior and emotion predicted who had a robust airway response. Interestingly, there was no relationship between behavioral inhibition and common asthma-related immune markers (e.g., immune cell numbers, inflammatory proteins). One possibility is that the relationship between behavioral inhibition and asthmatics is produced not by the immune system per se, but by the autonomic nervous system—the system that controls your heart, lungs, and guts and produces “fight or flight” and “rest and relax” responses to stimuli in the environment. Both behavioral inhibition and asthma have been related to alterations in the autonomic nervous system. It may be that alterations in the autonomic nervous system are a common link between behavioral inhibition and sensitive airways, which could be further investigated in future studies to sort out these mechanisms.

The take home message from our study, in concert with accumulating evidence from other research groups, is that variation in emotional life is related to health. Understanding the causal relationships between emotion and health (e.g., does emotional temperament like behavioral inhibition lead to reactive airways or do animals with reactive airways become behaviorally inhibited?) is the next critical step in this research program and will hopefully lead to interventions to promote well-being.

Photo credit: Kathy West CNPRC-UC Davis, copyright 2013